BIO CHEMISTRY MCQs

BIO CHEMISTRY MCQs

 

1. Neonatal tyrosinemia improves on administration of

• (A) Thiamin
• (B) Riboflavin
• (C) Pyridoxine
• (D) Ascorbic acid

2. Absence of phenylalanine hydroxylase causes

• (A) Neonatal tyrosinemia
• (B) Phenylketonuria
• (C) Primary hyperoxaluria
• (D) Albinism

3. Richner-Hanhart syndrome is due to defect in

• (A) Tyrosinase
• (B) Phenylalanine hydroxylase
• (C) Hepatic tyrosine transaminase
• (D) Fumarylacetoacetate hydrolase

4. Plasma tyrosine level in Richner-Hanhart syndrome is

•  (A) 1–2 mg/dL
• (B) 2–3 mg/dL
• (C) 4–5 mg/dL
• (D) 8–10 mg/dL

 5. Amount of phenylacetic acid excreted in the urine in phenylketonuria is

• (A) 100–200 mg/dL
• (B) 200–280 mg/dL
• (C) 290–550 mg/dL
• (D) 600–750 mg/dL

 6. Tyrosinosis is due to defect in the enzyme:

• (A) Fumarylacetoacetate hydrolase
• (B) p-Hydroxyphenylpyruvate hydroxylase
• (C) Tyrosine transaminase
• (D) Tyrosine hydroxylase

7. An important finding in Histidinemia is

• (A) Impairment of conversion of α-Glutamate to α-ketoglutarate
• (B) Speech defect
• (C) Decreased urinary histidine level
• (D) Patients can not be treated by diet

8. An important finding in glycinuria is

• (A) Excess excretion of oxalate in the urine
• (B) Deficiency of enzyme glycinase
• (C) Significantly increased serum glycine level
• (D) Defect in renal tubular reabsorption of glycine

9. Increased urinary indole acetic acid is diagnostic of

• (A) Maple syrup urine disease
• (B) Hartnup disease
• (C) Homocystinuia
• (D) Phenylketonuria

 10. In glycinuria daily urinary excretion of glycine ranges from

• (A) 100–200 mg
• (B) 300–500 mg
• (C) 600–1000 mg
• (D) 1100–1400 mg

 11. An inborn error, maple syrup urine disease is due to deficiency of the enzyme:

• (A) Isovaleryl-CoAhydrogenase
• (B) Phenylalnine hydroxylase
• (C) Adenosyl transferase
• (D) α-Ketoacid decarboxylase

12. Maple syrup urine disease becomes evident in extra uterine life by the end of

• (A) First week
• (B) Second week
• (C) Third week
• (D) Fourth week

 13. Alkaptonuria occurs due to deficiency of the enzyme:

• (A) Maleylacetoacetate isomerase
• (B) Homogentisate oxidase
• (C) p-Hydroxyphenylpyruvate hydroxylase
• (D) Fumarylacetoacetate hydrolase

14. An important feature of maple syrup urine disease is

• (A) Patient can not be treated by dietary regulation
• (B) Without treatment death, of patient may occur by the end of second year of life
• (C) Blood levels of leucine, isoleucine and serine are increased
• (D) Excessive brain damage

 15. Ochronosis is an important finding of

• (A) Tyrosinemia
• (B) Tyrosinosis
• (C) Alkaptonuria
• (D) Richner Hanhart syndrome

16. Phrynoderma is a deficiency of

• (A) Essential fatty acids
• (B) Proteins
• (C) Amino acids
• (D) None of these

17. The percentage of linoleic acid in safflower oil is

• (A) 73
• (B) 57
• (C) 40
• (D) 15

18. The percentage of polyunsaturated fatty acids in soyabean oil is

• (A) 62
• (B) 10
• (C) 3
• (D) 2

 19. The percentage of polyunsaturated fatty acids in butter is

• (A) 60
• (B) 37
• (C) 25
• (D) 3

 20. Dietary fibre denotes

• (A) Undigested proteins
• (B) Plant cell components that cannot be digested by own enzymes
• (C) All plant cell wall components
• (D) All non digestible water insoluble polysaccharide

21. A high fibre diet is associated with reduced incidence of

• (A) Cardiovascular disease
• (B) C.N.S. disease
• (C) Liver disease
• (D) Skin disease

 22. Dietary fibres are rich in

• (A) Cellulose
• (B) Glycogen
• (C) Starch
• (D) Proteoglycans

 23. Minimum dietary fibre is found in

• (A) Dried apricot
• (B) Peas
• (C) Bran
• (D) Cornflakes

 24. A bland diet is recommended in

• (A) Peptic ulcer
• (B) Atherosclerosis
• (C) Diabetes
• (D) Liver disease

 25. A dietary deficiency in both the quantity and the quality of protein results in

• (A) Kwashiorkar
• (B) Marasmus
• (C) Xerophtalmia
• (D) Liver diseases

 26. The deficiency of both energy and protein causes

• (A) Marasmus
• (B) Kwashiorkar
• (C) Diabetes
• (D) Beri-beri

27. Kwashiorkar is characterized by

• (A) Night blindness
• (B) Edema
• (C) Easy fracturability
• (D) Xerophthalmia

28. A characteristic feature of Kwashiorkar is

• (A) Fatty liver
•  (B) Emaciation
• (C) Low insulin lever
• (D) Occurrence in less than 1 year infant

 29. A characteristic feature of marasmus is

• (A) Severe hypoalbuminemia
• (B) Normal epinephrine level
•  (C) Mild muscle wasting
•  (D) Low insulin and high cortisol level

 30. Obesity generally reflects excess intake of energy and is often associated with the development of 

• (A) Nervousness
• (B) Non-insulin dependent diabetes mellitus
• (C) Hepatitis
• (D) Colon cancer

31. Atherosclerosis and coronary heart diseases are associated with the diet:

• (A) High in total fat and saturated fat
• (B) Low in protein
• (C) High in protein
• (D) High in carbohydrate

32. Cerebrovasular disease and hypertension is associated with

• (A) High calcium intake
• (B) High salt intake
• (C) Low calcium intake
• (D) Low salt intake

33. The normal range of total serum bilirubin is

• (A) 0.2–1.2 mg/100 ml
• (B) 1.5–1.8 mg/100 ml
• (C) 2.0–4.0 mg/100 ml
• (D) Above 7.0 mg/100 ml

34. The normal range of direct reacting (conjugated) serum bilirubin is

• (A) 0–0.1 mg/100 ml
• (B) 0.1–0.4 mg/100 ml
•  (C) 0.4–06 mg/100 ml
• (D) 0.5–1 mg/100 ml

 35. The normal range of indirect (unconjugated) bilirubin in serum is

•  (A) 0–0.1 mg/100 ml
•  (B) 0.1–0.2 mg/100 ml
• (C) 0.2–0.7 mg/100 ml
• (D) 0.8–1.0 mg/100 ml

36. Jaundice is visible when serum bilirubin exceeds

• (A) 0.5 mg/100 ml
• (B) 0.8 mg/100 ml
• (C) 1 mg/100 ml
• (D) 2.4 mg/100 ml

 37. An increase in serum unconjugated bilirubin occurs in

• (A) Hemolytic jaundice
• (B) Obstructive jaundice
•  (C) Nephritis
• (D) Glomerulonephritis

 38. One of the causes of hemolytic jaundice is

•  (A) G-6 phosphatase deficiency
•  (B) Increased conjugated bilirubin
• (C) Glucokinase deficiency
• (D) Phosphoglucomutase deficiency

39. Increased urobilinogen in urine and absence of bilirubin in the urine suggests

• (A) Obstructive jaundice
• (B) Hemolytic jaundice
• (C) Viral hepatitis
• (D) Toxic jaundice

40. A jaundice in which serum alanine transaminase and alkaline phosphatase are normal is

• (A) Hepatic jaundice
• (B) Hemolytic jaundice
• (C) Parenchymatous jaundice
• (D) Obstructive Jaundice

41. Fecal stercobilinogen is increased in

• (A) Hemolytic jaundice
• (B) Hepatic jaundice
• (C) Viral hepatitis
• (D) Obstructive jaundice

 42. Fecal urobilinogen is increased in

• (A) Hemolytic jaundice
• (B) Obstruction of biliary duct
• (C) Extrahepatic gall stones
• (D) Enlarged lymphnodes

43. A mixture of conjugated and unconjugated bilirubin is found in the circulation in

• (A) Hemolytic jaundice
•  (B) Hepatic jaundice
• (C) Obstructive jaundice
• (D) Post hepatic jaundice