bio chemistry MCQs with answer
bio chemistry MCQs with answer
1. During starvation, the first reserve nutrient to be
depleted is
(A) Glycogen
(B) Proteins
(C) Triglycerides
(D) Cholesterol
2. Synthesis of the following enzymes is increased during starvation.
(A) Digestive enzymes
(B) Gluconeogenic enzymes
(C) Urea cycle enzymes
(D) Glucokinase
3. In hypoparathyroidism
(A) Plasma calcium and inorganic phosphorous are low
(B) Plasma calcium and inorganic phosphorous are high
(C) Plasma calcium is low and inorganic phosphorous high
(D) Plasma calcium is high and inorganic phosphorous low
4. The number of amino acid residues in calcitonin in
(A) 9
(B) 32
(C) 51
(D) 84
5. Calcitonin is synthesised in
(A) Parathyroid glands
(B) Thyroid gland
(C) Pars intermedia of pituitary
(D) Adrenal cortex
6. Plasma calcium is lowered by
(A) Parathormone
(B) Calcitonin
(C) Aldosterone
(D) Deoxycorticosterone
(A) Glycogen
(B) Proteins
(C) Triglycerides
(D) Cholesterol
2. Synthesis of the following enzymes is increased during starvation.
(A) Digestive enzymes
(B) Gluconeogenic enzymes
(C) Urea cycle enzymes
(D) Glucokinase
3. In hypoparathyroidism
(A) Plasma calcium and inorganic phosphorous are low
(B) Plasma calcium and inorganic phosphorous are high
(C) Plasma calcium is low and inorganic phosphorous high
(D) Plasma calcium is high and inorganic phosphorous low
4. The number of amino acid residues in calcitonin in
(A) 9
(B) 32
(C) 51
(D) 84
5. Calcitonin is synthesised in
(A) Parathyroid glands
(B) Thyroid gland
(C) Pars intermedia of pituitary
(D) Adrenal cortex
6. Plasma calcium is lowered by
(A) Parathormone
(B) Calcitonin
(C) Aldosterone
(D) Deoxycorticosterone
7. α Cells of Islets of Langerhans secrete
(A) Insulin
(B) Glucagon
(C) Somatostatin
(D) Cholecystokinin
8. A/G ratio is
(A) Strength of proteins
(B) ratio of serum proteins
(C) ratio of ceruloplasmin
(D) None of these
9. Insulin is made up of
(A) A single polypeptide chain having 51 amino acid residues
(B) A single polypeptide chain having 84 amino acid residues
(C) A-chain having 21 and B-chain having 30 amino acid residues
(D) A-chain having 30 and B-chain having 21 amino acid residues
10. The number of amino acid residues in preproinsulin is
(A) 51
(B) 84
(C) 109
(D) 119
11. Pre-proinsulin contains a signal sequence having
(A) 9 amino acid residues
(B) 19 amino acid residues
(C) 27 amino acid residues
(D) 33 amino acid residues
12. The number of intra-chain disulphide bonds in pro-insulin:
(A) One
(B) Two
(C) Three
(D) Four
13. Pentagastrin is a
(A) Naturally occurring form of gastrin
(B) Inactive metabolite of gastrin
(C) Active metabolite of gastrin
(D) Synthetic form of gastrin
14. Secretion of gastrin is evoked by
(A) Entry of food into stomach
(B) Vagal stimulation
(C) Lower aliphatic alcohols
(D) All of these
15. Gastrin stimulates
(A) Gastric motility
(B) Gastric secretion
(C) Both (A) and (B)
(D) None of these
16. Secretin is made up of
(A) 17 amino acids
(B) 27 amino acids
(C) 37 amino acids
(D) 47 amino acids
17. Secretin causes all of the following except
(A) Secretion of pancreatic juice
(B) Secretion of bile
(C) Inhibition of gastric secretion
(D) Stimulation of intestinal motility
18. All of the following statements about cholecystokinin pancreozymin are true except
(A) It is secreted by mucosa of small intestine
(B) It stimulates secretion of pancreatic juice rich in enzymes
(C) It stimulates contraction of gall bladder
(D) It inhibits gastric motility
19. All of the following statements about pancreatic somatostain are true except
(A) It is secreted by δ cells of islets of Langerhans
(B) It stimulates the secretion of gastrin
(C) It inhibits the secretion of secretin
(D) It inhibits the secretion of cholecystokininpancreozymin
20. Histidine is converted into histamine by
(A) Carboxylation
(B) Decarboxylation
(C) Methylation
(D) Hydroxylation
21. Histamine is synthesised in
(A) Brain
(B) Mast cells
(C) Basophils
(D) All of these
22. Histamine causes all the following except
(A) Stimulation of gastric secretion
(B) Vasoconstriction
(C) Pruritus
(D) Increase in capillary permeability
23. H2-receptors are blocked by
(A) Diphenhydramine
(B) Mepayramine
(C) Pyrilamine
(D) Cimetidine
24. Serotonin is synthesised from
(A) Serine
(B) Phenylalanine
(C) Tyrosine
(D) Tryptophan
25. All the following statements about serotonin are true except
(A) It causes vasolidatation
(B) It causes bronchoconstriction
(C) It is metabolized by monoamine oxidase
(D) Its metabolite is 5-hydroxyindole acetic acid
26. All the following statements about angiotensin are true except
(A) Its precursor is an α2-globulin
(B) Its active form is an octapeptide
(C) It is a vasodilator
(D) It increases the secretion of aldosterone
27. Methyl dopa decreases blood pressure by
(A) Inhibiting the synthesis of catecholamines
(B) Antagonising the action of aldosterone
(C) Stimulating the release of renin
(D) Inhibiting the breakdown of angiotensin
28. Binding of gamma-aminobutyric acid to its receptors in brain increases the permeability of cell membrane to
(A) Cl–
(B) Na+
(C) K+
(D) Ca++
29. Binding of acetylcholine to its receptors increases the permeability of cell membrane to
(A) Ca++
(B) Na+
(C) K+
(D) Na+ and K+
30. All of the following are glycoproteins except
(A) Collagen
(B) Albumin
(C) Transferrin
(D) IgM
31. Sialic acids are present in
(A) Proteoglycans
(B) Glycoproteins
(C) Both (A) and (B)
(D) None of these
32. Hyaluronidase hydrolyses
(A) Hyaluronic acid
(B) Chondroitin sulphate
(C) Heparin
(D) Hyaluronic acid and chondroitin sulphate
33. The most abundant protein in bones is
(A) Collagen type I
(B) Collagen type II
(C) Collagen type III
(D) Non-collagen proteins
34. The most abundant collagen in cartilages is
(A) Type I
(B) Type II
(C) Type III
(D) Type IV
35. Collagen and elastin have the following similarity:
(A) Both are triple helices
(B) Both have hydroxyproline residues
(C) Both have hydrolysine residues
(D) Both are glycoproteins
36. Abnormal collagen structure is seen in all of the following except
(A) I-cell disease
(B) Osteogenesis imperfecta
(C) Menke’s disease
(D) Ehlers-Danlos sydrome
37. I-cell disease results from absence of the following from lysosomal enzymes:
(A) Signal sequence
(B) Mannose-6-phosphate
(C) Sialic acid
(D) A serine residue
38. In I-cell disease, lysosomal enzymes
(A) Are not synthesised
(B) Are inactive
(C) Lack signal sequence
(D) Cannot reach lysosomes
39. Renal glycosuria occurs due to
(A) Increased filtration of glucose in glomeruli
(B) Increased secretion of glucose by renal tubular cells
(C) Decreased reabsorption of glucose by renal tubular cells
(D) Increased conversion of glycogen into glucose in tubular cells
40. Haematuria can occur in
(A) Haemolytic anaemia
(B) Mismatched blood transfusion
(C) Yellow fever
(D) Stone in urinary tract
(A) Serine
(B) Phenylalanine
(C) Tyrosine
(D) Tryptophan
25. All the following statements about serotonin are true except
(A) It causes vasolidatation
(B) It causes bronchoconstriction
(C) It is metabolized by monoamine oxidase
(D) Its metabolite is 5-hydroxyindole acetic acid
26. All the following statements about angiotensin are true except
(A) Its precursor is an α2-globulin
(B) Its active form is an octapeptide
(C) It is a vasodilator
(D) It increases the secretion of aldosterone
27. Methyl dopa decreases blood pressure by
(A) Inhibiting the synthesis of catecholamines
(B) Antagonising the action of aldosterone
(C) Stimulating the release of renin
(D) Inhibiting the breakdown of angiotensin
28. Binding of gamma-aminobutyric acid to its receptors in brain increases the permeability of cell membrane to
(A) Cl–
(B) Na+
(C) K+
(D) Ca++
29. Binding of acetylcholine to its receptors increases the permeability of cell membrane to
(A) Ca++
(B) Na+
(C) K+
(D) Na+ and K+
30. All of the following are glycoproteins except
(A) Collagen
(B) Albumin
(C) Transferrin
(D) IgM
31. Sialic acids are present in
(A) Proteoglycans
(B) Glycoproteins
(C) Both (A) and (B)
(D) None of these
32. Hyaluronidase hydrolyses
(A) Hyaluronic acid
(B) Chondroitin sulphate
(C) Heparin
(D) Hyaluronic acid and chondroitin sulphate
33. The most abundant protein in bones is
(A) Collagen type I
(B) Collagen type II
(C) Collagen type III
(D) Non-collagen proteins
34. The most abundant collagen in cartilages is
(A) Type I
(B) Type II
(C) Type III
(D) Type IV
35. Collagen and elastin have the following similarity:
(A) Both are triple helices
(B) Both have hydroxyproline residues
(C) Both have hydrolysine residues
(D) Both are glycoproteins
36. Abnormal collagen structure is seen in all of the following except
(A) I-cell disease
(B) Osteogenesis imperfecta
(C) Menke’s disease
(D) Ehlers-Danlos sydrome
37. I-cell disease results from absence of the following from lysosomal enzymes:
(A) Signal sequence
(B) Mannose-6-phosphate
(C) Sialic acid
(D) A serine residue
38. In I-cell disease, lysosomal enzymes
(A) Are not synthesised
(B) Are inactive
(C) Lack signal sequence
(D) Cannot reach lysosomes
39. Renal glycosuria occurs due to
(A) Increased filtration of glucose in glomeruli
(B) Increased secretion of glucose by renal tubular cells
(C) Decreased reabsorption of glucose by renal tubular cells
(D) Increased conversion of glycogen into glucose in tubular cells
40. Haematuria can occur in
(A) Haemolytic anaemia
(B) Mismatched blood transfusion
(C) Yellow fever
(D) Stone in urinary tract
41. Haematuria can occur in all of the following except
(A) Acute glomerulonephritis
(B) Cancer of urinary tract
(C) Stone in urinary tract
(D) Mismatched blood transfusion
42. Chyluria can be detected by addition of the following to the urine:
(A) Sulphosalicylic acid
(B) Nitric acid
(C) Acetic anhydride
(D) Chloroform
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