Biology MCQs with Answer by General knowledge Solutions

Biology MCQs with Answer   by General knowledge Solutions

                                                                                 

01. Iodide uptake by thyroid gland is decreased by

(A) Thicyanate

(B) Thiouracil

(C) Thiourea

(D) Methimazole

02. Binding of growth hormone to its receptor results in phosphorylation of

(A) JAK-2

(B) Growth hormone receptor

(C) STATs

(D) All of these

 03. Binding of growth hormone to its receptor results in increased transcription of

(A) c-fos gene

(B) c-myc gene

(C) p-53 gene

(D) None of these

04. Activation of IRS-1, PI-3 kinase and GRB2 is brought about by

(A) Glucagon

(B) Insulin

(C) Prolactin

(D) IGF-2

05. The protein IRS-1 is phosphorylated by

(A) Protein kinase A (B) Protein kinase C

(C) Tyrosine kinase activity of insulin receptor

(D) Tyrosine kinase activity of IGF-1 receptor

06. Phosphorylated IRS-1 activates GRB-2 which is

(A) G-protein receptor binding protein-2

(B) Growth factor receptor binding protein-2

(C) Growth hormone receptor binding protein-2

(D) Glucocorticoid receptor binding protein-2

07. STAT proteins are

(A) Thermostat proteins of brain

(B) Glucostat proteins of hepatocyte cell membrane

(C) Short term activators of translation

(D) Signal transduction and activators of transcription

08. Activated phospholipase C acts on

(A) Phosphatidyl inositol-4, 5-biphosphate

(B) Inositol-1, 4, 5-triphosphate

(C) Protein kinase C

(D) Pl-3 kinase

 09. Phospholipase C is activated by

(A) Gs proteins

(B) Gi proteins

(C) Gq proteins

(D) G12 proteins

10. Proteoglycans are made up of proteins and

(A) Glucosamine

(B) Mannosamine

(C) Sialic acid

(D) Mucopolysaccharides

 11 Sweat chlorides are increased in

(A) Cystic fibrosis

(B) Pancreatic cancer

(C) Acute pancreatitis

(D) None of these

12. All the following statements about cystic fibrosis are correct except

(A) It is inherited as an autosomal recessive disease

(B) It affects a number of exocrine glands

(C) It causes increased sweating

(D) Sweat chlorides are above 60 mEq/L in this disease

13. Radioactive iodine uptake by thyroid gland 24 hours of a test dose is

(A) 1.5–15% of the test done

(B) 15–20% of the test done

(C) 20–40% of the test done

(D) 50–70% of the test done

14. Radioactive iodine uptake by thyroid gland is increased in

(A) Endemic goitre

(B) Hyperthyroidism

(C) Myxoedema

(D) Creatinism

 15. Normal range of total thyroxine in serum is

(A) 0.8–2.4 ng/dl

(B) 0.8–2.4 µg/dl

(C) 5–12 ng/dl

(D) 5–12 µg/dl

 16. Normal range of total tri-iodothyronine in serum is

(A) 0.1–0.2 ng/dl

(B) 0.1–0.2 µg/dl

(C) 0.8–2.4 ng/dl

(D) 0.8–2.4 µg/dl

17. Administration of TSH increases serum T3 and T4 in

(A) Hyperthyroidism of pituitary origin

(B) Hyperthyroidism of thyroid origin

(C) Hypothyroidism of pituitary origin

(D) Hypothyroidism of thyroid origin

18. High level of T3 and T4 and low TSH in serum indicates

(A) Hyperthyroidism of pituitary origin

(B) Hypothyroidism of pituitary origin

(C) Hyperthyroidism of thyroid origin

(D) Hypothyroidism of thyroid origin

19. BMR is increased in

(A) Endemic goitre

(B) Thyrotoxicosis

(C) Myxoedema

(D) Cretinism

 20. Which one of the following statements correctly describes eukaryotic DNA?

(A) If uses DNA polymerase with nuclease activities

(B) It is replicated bidirectionally at many points

(C) It contains no repetitive DNA

(D) It is nonlinear

21. Which one of the following causes frame shift mutation?

(A) Transition

(B) Transversion

(C) Deletion

(D) Substitution of purine to pyrimidine

 22. The second messenger for many hormones is

 (A) ATP

 (B) cyclic AMP

 (C) cGMP

 (D) UTP

23. The most potent hormone concerned with the retention of sodium in the body is

(A) Cortisone

(B) Aldosterone

(C) Corticosterone

(D) Cortisol

 24. Aspirin blocks the synthesis of

(A) Prostaglandins only

(B) Prostacyclins only

(C) Thromboxanes only

(D) All of these

25. Retention of sodium in the body leads to a retention of

(A) Potassium

(B) Water

(C) Potassium and water

(D) Neither potassium nor water

26. cAMP is so called because it is formed during

(A) TCA cycle

(B) Urea cycle

(C) Rhodopsin cycle

(D) It has a cyclic structure

 27. Protein bound iodine is _________ bound to protein.

(A) Iodine

(B) Thyroid hormones

(C) Thyroxine

(D) Tri iodo thyronine

 28. In hypophysectonized animals, fasting produces

(A) Severe hyperglycemia

(B) Hypoglycemia

(C) No change in blood sugar

(D) Mild hyper glycemia

 29. Calcitomica is antagonist to

 (A) Serotonin

 (B) Thyroxine

 (C) Tri iodo thyronine

 (D) Para thyroid hormone

 30. There is polyuria without glycosuria in this disorder

 (A) Diabetes insipidus

 (B) Diabetes millitus

 (C) Bronze diabetes

 (D) Juvenile diabetes

31. In hyperparathyroidism there is

 (A) Hypocalcemia

 (B) Hypophophatemia

 (C) Hypokalemia

 (D) Hyperkalemia

 32. Insulin resistance is encountered in

 (A) Addison’s disease

 (B) Hypothyroidism

 (C) Hypopituctarism

 (D) Acromegaly

 33. Richest source of prostaglandins in a human male is

 (A) Blood

 (B) Urine

 (C) Semen

 (D) C.S.F.

34. One of the following is not used as a second messenger by hormones:

(A) mRNA

(B) cAMP

(C) Calcium ions

(D) Myoinisotol 1, 4, 5 triphosphate

35. This pancreatic hormone increases the blood-sugar level:

(A) Insulin

(B) Glucagon

(C) Pancreozymin

(D) Pancreatic polypeptide

36. Which one of the following statements is fully correct?

(A) Hormones are needed in the diet

(B) Hormones can be elaborated only by endocrine glands

(C) All the hormones enter the cells and perform their function

 (D) Hormones are substance synthesized in the body in small quantities and control and regulate metabolic events

 37. T3 is

(A) Thyroxine

(B) Triodo thyronine

(C) Triodo tyrosine

(D) Reverse tri iodo thyronine

 38. Whcih of the following hormone is a peptide of less than ten amino acids?

(A) Insulin

(B) Growth hormone

(C) Oxytocin

(D) Parathyroid hormone

39. Tyrosine hydroxylase is inhibited by

(A) Catecholamines

(B) α−Methyldopa

(C) Phenylalanine

(D) Vanillyl mandelic acid

 40. Urinary excretion of vanillyl madelic acid is increased in

(A) Phaeochromocytoma

(B) Cushing’s syndrome

(C) Carcinoid syndrome

(D) Aldosteronism

Answer 

01. A 02. D 03. A 04. B 05. B 06. B 07. D 08. A 09. C 10. D 11. A 12. C 13. C 14. B 15. D 16. B 17. C 18. C 19. B 20. C 21. C 22. B 23. B 24. D 25. B 26. D 27. B 28. B 29. D 30. A 31. B 32. D 33. C 34. A 35. B 36. D 37. B  38. C  39. A 40. A