Biology MCQs with Answer (part 2) by General knowledge Solutions

Biology MCQs with Answer (part 2)  by General knowledge Solutions

                                                                                   

1. The activity of HMG-CoA reductase is inhibited by

(A) A fungal inhibitor mevastatin

(B) Probucol

(C) Nicotinic acid

(D) Clofibrate

 2. Hypolipidemic drugs reduce serum cholesterol and triacylglycerol. The effect of clofibrate is attributed to

(A) Block in absorption from G.I.T.

(B) Decrease in secretion of triacylglycerol and cholesterol containing VLDL by liver

(C) Block in the reabsorption of bile acids

(D) Decreased synthesis of cholesterol

3. In biosynthesis of cholesterol triparanol inhibits the activity of the enzyme:

 (A) ∆24 Reductase

 (B) Oxidosqualene-lanosterol cyclase

 (C) Isomerase

 (D) Squalene epoxidase

4. HMG-CoA reductase activity is increased by administration of the hormone:

 (A) Insulin

(B) Glucagon

(C) Epinephrine

(D) Glucocorticoids

 5. The principal sterol excreted in feces is

(A) Coprostanol

(B) Zymosterol

(C) Lanosterol

(D) Desmosterol

 6. The principal rate limiting step in the biosynthesis of bile acids is at the

(A) 7-Hydroxylase reaction

(B) 12 α-Hydroxylase reaction

(C) Conjugation reaction

(D) Deconjugation reaction

 7. Hypercholesterolemia is found in

(A) Xanthomatosis

(B) Thyrotoxicosis

(C) Hemolytic jaundice

(D) Malabsorption syndrom

8. Hypocholesterolemia is found in

(A) Thyrotoxicosis

(B) Diabetes mellitus

(C) Obstructive jaundice

(D) Nephrotic syndrome

9. The major source of extracellular cholesterol for human tissue is

(A) Very low density lipoprotein

(B) High density lipoprotein

(C) Low density lipoprotein

(D) Albumin

 10. Correct ordering of lipoprotein molecules from lowest to the greater density is

 (A) LDL, IDL, VLDL, chylomicron

(B) Chylomicron, VLDL, IDL, LDL

(C) VLDL, IDL, LDL, chylomicron

(D) LDL, VLDL, IDL, chylomicron

11. In Hurler’s syndrome, urine shows the presence of

(A) Keratan sulphate I

(B) Chondroitin sulphate

(C) Dermatan sulphate and heparan sulphate

(D) Keratan sulphate II

12. Defective enzyme in Hunter’s syndrome is

(A) α-L-iduronidase

(B) Iduronate sulphatase

(C) Arylsulphatase B

(D) C-acetyl transferase

13. In Hunter’s syndrome

(A) There is progressive corneal opacity

(B) Keratan sulphate is excreted in the urine

(C) Enzyme defective is arylsulphatase B

(D) Hearing loss is perceptive

14. An important feature of Von-Gierke’s disease is

 (A) Muscle cramps

 (B) Cardiac failure

(C) Hypoglycemia

(D) Respiratory alkalosis

 15. The affected organ in Mc Ardle’s syndrome is

(A) Liver

(B) Kidney

(C) Liver and Heart

(D) Skeletal muscle

 16. Refsum’s disease is due to deficiency of the enzyme:

(A) Pytantate-α-oxidase

(B) Glucocerebrosidase

(C) Galactocerebrosidase

(D) Ceramide trihexosidase

17. An important finding in Refsum’s disease is

(A) Accumulation of ceramide trihexoside in the kidney

(B) Accumulation of phytanic acid in the blood and tissues

(C) Accumulation of gangliosides in brain and spleen

(D) Skin eruptions

18. α-Galactosidase enzyme is defective in

(A) Tay-sach’s disease

(B) Refsum’s disease

(C) Sandhoff’s disease

(D) Fabry’s disease

19. The hypothesis to explain enzyme– substrate complex formation:

 (A) Lock and key model

 (B) Induced fit theory

(C) Proenzyme theory

(D) Both (A) and (B)

20. An important finding in Tay-sach’s disease is

(A) Renal failure

(B) Accumulation of gangliosides in brain and spleen

(C) Cardiac failure

 (D) Anemia

 21. The enzyme deficient in Krabbe’s disease is

(A) Hexosaminidase A

(B) Arylsuphatase A

(C) β-Galactosidase

(D) α-Fucosidase

 22. The enzyme ceramidase is deficient in

(A) Farber’s disease

(B) Fabry’s disease

(C) Sandhoff’s disease

(D) Refsum’s disease

 23. Niemann-Pick disease is due to deficiency of the enzyme

 (A) Ceramidase

 (B) Glucocerebrosidase

 (C) Galactocerebrosidase

 (D) Sphingomyelinase

24. Wolman’s disease is due to deficiency of

(A) Cholesteryl ester hydrolase

(B) Hexosaminidase A

(C) α-Fucosidase

(D) Arylsulphatase A

 25. The enzyme deficient in Sandhoff’s disease is

(A) α-Fucosidase

(B) Hexosaminidase A and B

(C) β-Galactosidase

(D) β-Glucosidase

26. Jamaican vomiting sickness is due to inactivation of the enzyme

(A) Pyruvate carboxylase

(B) Acyl-Co-A synthetase

(C) Acyl-Co-A dehydrogense

(D) Thiolase

 27. Zellweger’s syndrome is due to inherited absence of

(A) Peroxisomes

(B) Phospholipase A1

(C) Acyl-Co-A dehydrogenase

(D) Thiolase

 28. Bassen-Kornzweig syndrome is due to

(A) Absence of Apo-C-II

(B) Defect in Apo-B synthesis

(C) Absence of Apo-E

(D) Absence of Apo-D

29. Enzyme deficient in Hyperammonemia type II is

(A) Glutamine synthetase

(B) Glutaminase

(C) Ornithine transcarbamoylase

(D) Carbamoylphosphate synthetase

30. An important finding in Hyperammonemia type II is

(A) Increased serum gluatmine level

(B) Enlarged liver

(C) Mental retardation

(D) Increased carbamoyl phosphate synthetase level

 31. Absence of the enzyme argininosuccinate synthetase causes

(A) Argininosuccinic aciduria

(B) Hyperargininemia

(C) Tricorrhexis nodosa

(D) Citrullinemia

 32. Tricorrhexis nodosa is a characteristic finding of

(A) Argininosuccinic aciduria

(B) Citrullinemia

(C) Phenylketonuria

(D) Hyperargininemia

 33. Elevated blood argininosuccinate level is found in

(A) Hyperargininemia

(B) Argininosuccinic aciduria

(C) Citrullinemia

 (D) Tyrosinosis

 34. Hyperargininemia, a defect in urea synthesis develops due to deficiency of the enzyme:

(A) Ornithine transcarbamoylase

(B) Argininosuccinase

(C) Arginase

(D) Argininosuccinate synthetase

35. Albinism is due to deficiency of the enzyme:

(A) Phenylalanine hydroxylase

(B) Tyrosinase

(C) p-Hydroxyphenylpyruvic acid oxidase

(D) Tyrosine dehydrogenase

 36. Neonatal tyrosinemia is due to deficiency of the enzyme:

(A) p-Hydroxyphenylpyruvate hydroxylase

(B) Fumarylacetoacetate hydrolase

(C) Phenylalanine hydroxylase

(D) Tyrosine dehydrogenase

37. Which of the following is a substratespecific enzyme?

(A) Hexokinase

(B) Thiokinase

(C) Lactase

(D) Aminopeptidase

 38. Coenzymes combine with

(A) Proenzymes

(B) Apoenzymes

(C) Holoenzymes

(D) Antienzymes

 39. Coenzymes are required in which of the following reactions?

(A) Oxidation-reduction

(B) Transamination

(C) Phosphorylation

(D) All of these

40. Which of the following coenzyme takes part in hydrogen transfer reactions?

(A) Tetrahydrofolate

(B) Coenzyme A

(C) Coenzyme Q

(D) Biotin

41. Which of the following coenzyme takes part in oxidation-reduction reactions?

(A) Pyridoxal phosphate

(B) Lipoic acid

(C) Thiamin diphosphate

(D) None of these

42. In conversion of glucose to glucose-6- phsophate, the coenzyme is

 (A) Mg++

 (B) ATP

 (C) Both (A) and (B)

 (D) None of these

 43. A coenzyme required in transamination reactions is

(A) Coenzyme A

(B) Coenzyme Q

(C) Biotin

(D) Pyridoxal phosphate

44. Coenzyme A contains a vitamin which is

(A) Thiamin

(B) Ascorbic acid

(C) Pantothenic acid

(D) Niacinamide

Answer

1. A 2. B 3. A 4. A 5. A 6. A 7. A 8. A 9. C 10. B 11. C

12. B 13. D 14. C 15. D 16. A 17. B 18. D 19. C 20. B 21. C 22. A 23. D 24. A 25. B 26. C 27. A 28. B 29. C 30. C 31. A 32. D 33. A 34. B 35. C 36. B 37. C 38. B 39. D 40. C 41. B 42. B 43. D 44. C