Biology MCQs with Answer (part 2) by General knowledge Solutions

Biology MCQs with Answer (part 2)  by General knowledge Solutions

                                                                           

1. The rate of citric acid cycle is controlled by the allosteric enzyme:

(A) Aconitase

(B) Fumarase

(C) Fumarase

(D) Malate dehydrogenase

2. In the erythrocytes, the net production of ATP molecules by the Rapport-Leubering pathway is

(A) 0

(B) 2

(C) 4

(D) 8

3. The ratio that most closely approximates the number of net molecules of ATP formed per mole of glucose utilized under aerobic conditions to the net number formed under anaerobic conditions is

(A) 4:1

(B) 13:1

(C) 18:1

(D) 24:1

4. The pathway of glycogen biosynthesis involves a special nucleotide of glucose. In the reaction below, NuDP stands for NuDP Glucose + glycogenn → NuDP + glycogenn+1

(A) ADP

(B) GDP

(C) UDP

(D) CDP

5. Glucose 6-phosphate is converted to glucose 1-phosphate in a reaction catalysed by the enzyme phosphoglucomutase, which is

(A) Phosphorylated

(B) Dephosphorylated

(C) Phosphorylated-dephosphorylated

(D) Phosphorylated-dephosphorylatedrephosphorylated

 6. The glycogen content of the liver is upto

(A) 6%

(B) 8%

(C) 10%

(D) 12%

7. In glycogenesis a branch point in the molecule is established by the enzyme

(A) Amylo[1→ 4][1→ 6] transglucosidase

(B) α [1→ 4] α [1→ 4] Glucan transferase

 (C) Amylo [1→ 6] glucosidase

(D) Glycogen synthase

 8. In glycogenolysis, the enzyme which transfers a trisaccharide unit from one branch to the other exposing 1→ 6 branch point is

(A) Phosphorylase

(B) α-[1→ 4]→ α-[1→ 4]→ Glucan transferase

(C) Amylo [1→ 6] glucosidase

(D) Amylo[1→ 4]→ [1→ 6] transglucosidase

 9. In the synthesis of glycogen from glucose the reversible step is

(A) Glucose → glucose 6-phosphate

(B) Glucose 6-phosphate → glucose 1-phosphate

(C) Glucose 1-phosphate → UDP glucose

(D) UDP glucose → glycogen

 10. The enzyme glucose-6-phosphatase which catalyses the conversion of glucose 6-phosphate to glucose is not found in

(A) Liver

(B) Muscle

(C) Intestine

(D) Kidney

11. Allosteric activator of glycogen synthase is

(A) Glucose

(B) Glucose-6-Phosphate

(C) UTP (D) Glucose-1-phosphate

12. Action of glycogen synthase is inhibited by

(A) Insulin

(B) Glucose

(C) Mg2+

(D) Cyclic AMP

13. The hormone activating the glycogen synthase activity is

(A) Insulin

(B) Glucagon

(C) Epinephrine

(D) ACTH

 14. Characteristic features of active site are

(A) Flexible in nature

(B) Site of binding

(C) Acidic

(D) Both (A) and (B)

 15. Von Gierke’s disease is characterized by the deficiency of

(A) Glucose-6-phosphatase

(B) α -1→ 4 Glucosidase

(C) 1→ 6 Glucosidase

(D) Liver phosphorylase

16. Cori disease (Limit dextrinosis) is caused due to absence of

(A) Branching enzyme

(B) Debranching enzyme

(C) Glycogen synthase

(D) Phosphorylase

17. Mc Ardle’s syndrome is characterized by the absence of

 (A) Liver phosphorylase

(B) Muscle phosphorylase

(C) Branching enzyme

(D) Debranching enzyme

18. Pompe ’s d isease is caused due to deficiency of

 (A) Lysosomal α-1→4 and 1→6-glucosidase

(B) Glucose-6-phosphatase

(C) Glycogen synthase

(D) Phosphofructokinase

19. Amylopectinosis is caused due to absence of

(A) Debranching enzyme

(B) Branching enzyme

(C) Acid maltase

(D) Glucose-6-phosphatase

20. Her’s disease is characterized by deficiency of

(A) Muscle phosphorylase

(B) Liver phosphorylase

(C) Debranching enzyme

(D) Glycogen synthase

21. Tarui disease is characterized by the deficiency of the enzyme:

 (A) Liver phosphorylase

(B) Muscle phosphorylase

(C) Muscle and erythrocyte phosphofructokinase

(D) Lysosomal acid maltase

22. The hexose monophosphate pathway includes the enzyme:

(A) Maltase dehydrogenase

(B) Hexokinase

(C) α-Ketoglutarate dehydrogenase

(D) Glucose-6-phosphate dehydrogenase

 23. The hydrogen acceptor used in pentose phosphate pathway is

(A) NAD

 (B) NADP

(C) FAD

(D) FMN

 24. The enzymes of the pentose phosphate pathway are found in the

 (A) Cytosol

(B) Mitochondria

(C) Nucleus

(D) Endoplasmic reticulum

25. In pentose phosphate pathway, D-ribulose5-phosphate is converted to D-ribose-5- phosphate by the enzyme:

(A) Fumarase

(B) Ketoisomerase

(C) G-6-PD

(D) Epimerase

26. The transketolase enzyme in the pentose phosphate pathway requires the B vitamin.

 (A) Pantothenic acid

(B) Thiamin

(C) Riboflavin

(D) Nicotinic acid

 27. Xylulose-5-phosphate serves as a donar of active glycolaldehyde, the acceptor is

 (A) Erythrose 4-phosphate

(B) Ribose 5-phosphate

(C) Glyceraldehyde 3-phosphate

(D) Sedoheptulose 7-phosphate

28. Pentose phosphate pathway is of significance because it generates

(A) NADPH for reductive synthesis

(B) Regenerates glucose 6-phosphate

(C) Generates fructose 6-phosphate

(D) Forms glyceraldehyde 3-phosphate

29. The pentose phosphate pathway protects erythrocytes against hemolysis by assisting the enzyme:

(A) Superoxide dismutase

(B) Catalase

 (C) Glutathionic peroxidase

(D) Cytochrome oxidase

30. Hemolytic anemia is caused by the deficiency of certain enzymes of the pentose phosphate pathway, the principal enzyme involved is

(A) Glucose-6-phosphate dehydrogenase

(B) Aldolase

(C) Fructose 1, 6-bisphosphatase

(D) Phosphohexose isomerase

31. The sites for gluconeogenesis are

 (A) Liver and kidney

 (B) Skin and pancreas

(C) Lung and brain

(D) Intestine and lens of eye

 32. An enzyme involved in gluconeogenesis is

(A) Pyruvate kinase

(B) Pyruvate carboxylase

(C) Hexokinase

(D) Phosphohexose isomerase

 33. The enzyme pyruvate carboxylase is present in

(A) Cytosol

(B) Mitochondria

(C) Nucleus

(D) Golgi bodies

34. The enzyme phosphoenolpyruvate carboxykinase catalyses the conversion of oxaloacetate to phosphoenolpyruvate requires

(A) ATP

(B) ADP

(C) AMP

(D) GTP

35. The enzyme glucose 6-phosphatase is present in

(A) Liver

(B) Muscle

(C) Adipose tissue

 (D) Brain

36. In gluconeogensis, an allosteric activator required in the synthesis of oxaloacetate from bicarbonate and pyruvate, which is catalysed by the enzyme pyruvate carboxylase is

(A) Acetyl CoA

(B) Succinate

(C) Isocitrate

(D) Citrate

 37. The number of ATP molecules required to convert 2 molecules of lactate into glucose in mammalian liver is

 (A) 2

(B) 4

(C) 5

(D) 6

38. For conjugation with many enogenous and exogenous substances before elimination in urine, the uronic acid pathway provides

(A) Active glucuronate

(B) Gulonate

(C) Xylulose

(D) Xylitol

39. UDP glucose is converted to UDP glucurronate, a reaction catalysed by UDP glucose dehydrogenase requires

 (A) NAD+

(B) FAD

(C) NADP

(D) FMN

40. Pentosuria is a rare hereditary disease is characterized by increased urinary excretion of

(A) L-xylulose

 (B) Xylitol

(C) Xylulose 5-phosphate

(D) Ribose 5-phosphate

 41. The enzyme involved in essential pentosuria is

(A) Reductase

(B) Hydroxylase

(C) Isomerase

(D) Racemase

 42. Galactose is synthesized from glucose in

 (A) Mammary gland

 (B) Intestine

(C) Kidney

(D) Adipose tissue

 43. Galactose is readily converted to glucose in

 (A) Liver

(B) Intestine

(C) Kidney

 (D) Adipose tissue

44. Galactose 1-phosphate is converted to uridine diphosphate galactose, the reaction is catalysed by the enzyme:

(A) Glactokinase

(B) Galactose 1-phosphate uridyl transferase

(C) Uridine diphospho galactose 4-epimerase

(D) UDP glucose pyrophosphorylase

45. The best known cause of galactosemia is the deficiency of

(A) Galactose 1-phosphate and uridyl transferase

(B) Phosphoglucomutase

(C) Galactokinase

(D) Lactose synthase

Answers

1. C 2. A 3. C 4. C 5. D 6. A 7. A 8. B 9. B 10. B 11. B 12. C 13. A 14. D 15. A 16. B 17. B 18. A 19. B 20. B 21. C 22. D 23. B 24. A 25. B 26. B 27. A 28. A 29. C 30. A 31. A 32. B 33. B 34. D 35. A 36. A 37. D 38. A 39. A 40. A 41. A 42. A 43. A 44. B 45. A