Biology MCQs with Answer (part 1) by General knowledge Solutions
Biology MCQs with Answer (part 1) by General knowledge Solutions
0. In the biosynthesis of the iron protoporphyrin, the
product of the condensation between succinyl-CoA and glycine is
(A) α-Amino β-ketoadipic acid
(B) δ-Aminolevulinate
(C) Hydroxymethylbilane
(D) Uroporphyrinogen I
1. Porphyrin
synthesis is inhibited in
(A) Mercury poisoning
(B) Lead poisoning
(C) Manganese poisoning
(D) Barium poisoning
2. During synthesis of porphyrins, synthesis of δ-amino
levulinic acid occurs in
(A) Mitochondria
(B) Cytosol
(C) Both in mitochondria and cytosol
(D) Ribosomes
3. In the biosynthesis of heme, condensation between
succinyl CoA and glycine requires
(A) NAD+
(B) FAD
(C) NADH + H+
(D) B6-phosphate
4. In mammalian liver the rate controlling enzyme in
porphyrin biosynthesis is
(A) ALA synthase
(B) ALA hydratase
(C) Uroporphyrinogen I synthase
(D) Uroporphyrinogen III cosynthase
5. The condensation of 2 molecules of δ-aminolevulinate
dehydratase contains
(A) ALA synthase
(B) ALA hydratase
(C) Uroporphyrinogen synthase I
(D) Uroporphyrinogen synthase III
6. The enzyme
δ-aminolevulinate dehydratase contains
(A) Zinc
(B) Manganese
(C) Magnesium
(D) Calcium
7. A cofactor required for the activity of the enzyme ALA
dehydratase is
(A) Cu
(B) Mn
(C) Mg
(D) Fe
8. The number of
molecules of porphobilinogen required for the formation of a tetrapyrrole i.e.,
a porphyrin is
(A) 1
(B) 2
(C) 3
(D) 4
9. Conversion of the linear tetrapyrrole hydroxymethylbilane
to uroporphyrinogen III
(A) Occurs spontaneously
(B) Catalysed by uroporphyrinogen I synthase
(C) Catalysed by uroporphyrinogen III cosynthase
(D) Catalysed by combined action of uroporphyrinogen I
synthase and uroporphyrinogen III cosynthase
10. Conversion of uroporphyrinogen III to coprophyrinogen
III is catalysed by the enzyme.:
(A) Uroporphyrinogen
decarboxylase
(B)
Coproporphyrinogen oxidase
(C) Protoporphyrinogen oxidase
(D) Ferrochelatase
11. The synthesis of
heme from protophyrin III is catalysed by the enzyme:
(A) ALA synthase
(B) Ferroreductase
(C) Ferrooxidase
(D) Ferrochelatase
12. Many xenobiotics
(A) Increase hepatic ALA synthase
(B) Decrease hepatic ALA sythase
(C) Increase hepatic ALA dehydrase
(D) Decrease hepatic ALA dehydrase
13. Acute
intermittent porphyria (paraoxymal porphyria) is caused due to deficiency of
(A) Uroporphyrinogen I synthase
(B) ALA synthase
(C) Coproporphyrinogen oxidase
(D) Uroporphyrinogen decarboxylase
14. The major symptom of acute intermittent porphyria
includes
(A) Abdominal pain
(B) Photosensitivity
(C) No neuropsychiatric signs
(D) Dermatitis
15. The
characteristic urinary finding in acute intermittent porphyria is
(A) Increased quantity of uroporphyrin
(B) Increased quantity of coproporphyrin I
(C) Increased quantity of coproporphyrin III
(D) Massive quantities of porphobilinogen
16. The enzyme
involved in congenial erythropoietic porphyria is
(A) Uroporphyrinogen I synthase
(B) Uroporphyrinogen III cosynthase
(C) Protoporphyrinogen oxidase
(D) Ferrochelatase
17. Main symptoms of
congenital erythropoietic porphyria is
(A) Yellowish teeth
(B) Photosensitivity
(C) Abdominal pain
(D) Brownish urine
18. The probable
cause of porphyria cutanea tarda is deficiency of
(A) Uroporphyrinogen oxidase
(B) Coproporphyrinogen oxidase
(C) Protoporphyrinogen oxidase
(D) Uroporphyrinogen I synthase
19. The characteristic urinary finding in porphyria cutanea
tarda is
(A) Increased quantity of porphobilinogen
(B) Increased quantity of red cell protoporphyrin
(C) Increased quantity of uroporphyrin
(D) Increased quantity of δ-ALA
20. Hereditary coproporphyria is caused due to deficiency of
(A) Protoporphyrinogen oxidase
(B) ALA synthase
(C) ALA dehydratase
(D) Coproporphyrinogen oxidase
21. The enzyme
involved in variegate porphyria is
(A) Protoporphyrinogen oxidase
(B) Coproporphyrinogen oxidase
(C) Uroporphyrinogen
decarboxylase
(D) ALA decarboxylase
22. Protoporphyria (erythrohepatic) is characterized by the
deficiency of
(A) ALA synthase
(B) ALA hydratase
(C) Protophyrinogen oxidae
(D) Ferrochelatase
23. The amount of coproporphyrins excreted per day in feces
is about
(A) 10–50 µgs
(B) 100–150 µgs
(C) 200–250 µgs
(D) 300–1000 µgs
24. The
immunoglobulins are differentiated and also named on the basis of
(A) Electrophoretic mobility
(B) Heat stability
(C) Molecular weight
(D) Sedimentaiton coefficient like 7 S, 19 S etc.
25. The
immunoglobulins are classified on the basis of
(A) Light chains
(B) Heavy chains
(C) Carbohydrate content
(D) Electrophoretic mobility
26. All
immunoglobulins contain
(A) 4 L chains
(B) 4 H chains
(C) 3 L chains
(D) 2 L chains and 2 H chains
27. An immunoglobulin
molecule always contains
(A) 1 κ and 3 λ type of chains
(B) 2 κ and 2 λ type of chains
(C) 3 κ and 1λ type of chains
(D) 2 κ and 2 λ chains
28 . The number of
types of H chains identified in human is
(A) 2
(B) 3
(C) 4
(D) 5
29. The number of
hypervariable region in L chain is
(A) 1
(B) 2
(C) 3
(D) 4
30. The number of
hypervariable region in H chain is
(A) 1
(B) 2
(C) 3
(D) 4
31. Type γ H chain is present in
(A) Ig G
(B) Ig A
(C) Ig M
(D) Ig D
32. Type α H chain is
present in
(A) Ig E
(B) Ig A
(C) Ig M
(D) Ig D
33. Type µ H chain is
present in
(A) Ig G
(B) Ig A
(C) Ig M
(D) Ig D
34. Type δ H chain is
present in
(A) Ig G
(B) Ig A
(C) Ig M
(D) Ig D
35. Type ε H chain is
present in
(A) Ig A
(B) Ig M
(C) Ig D
(D) Ig E
36. A ‘J’ chain is present in
(A) Ig D
(B) Ig M
(C) Ig G
(D) Ig E
37. A secretory protein T chain (T protein) is present in
(A) Ig A
(B) Ig M
(C) Ig D
(D) Ig E
38. A pentamer
immunoglobulin is
(A) Ig G
(B) Ig A
(C) Ig M
(D) Ig E
39. The portion of the immunoglobulin molecule that binds
the specific antigen is formed by
(A) Variable regions of H and L chains
(B) Constant region of H chain
(C) Constant region of L chain
(D) Hinge region
0. A 1. B 2. A 3. D 4. A 5. B 6. A 7. A 8. D 9. D 10. A 11.
D 12. A 13. A 14. A 15. D 16. B 17. B 18. A 19. C 20. D 21. A 22. D 23. D 24. D
25. B 26. D 27. D 28. D 29. C 30. D 31. A 32. B 33. C 34. D 35. D 36. B 37. A 38.
C 39. A
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