BIO CHEMISTRY MCQs (PART 1) by General knowledge Solutions

              BIO CHEMISTRY MCQs (PART 1) by General knowledge Solutions

                                                                 

1. Which of the following is not essential fatty acids?

• (A) Oleic acid
• (B) Linoleic acid
• (C) Arachidonic acid
• (D) Linolenic acid

2. The caloric value of lipids is

• (A) 6.0 Kcal/g
• (B) 9.0 Kcal/g
• (C) 15.0 Kcal/g
• (D) 12.0 Kcal/g

3. The maximum number of double bonds present in essential fatty acid is

• (A) 2
• (B) 3
•  (C) 4
• (D) 5

4. Prostaglandin synfhesis is increased by activating phospholipases by

• (A) Mepacrine
•  (B) Angiotensin II
• (C) Glucocorticoids
• (D) Indomenthacin

5. Selwanof’s test is positive in

• (A) Glucose
• (B) Fructose
• (C) Galactose
• (D) Mannose

6. Spermatozoa in seminal fluid utilises the following sugar for metabolism:

• (A) Galactose
• (B) Glucose
• (C) Sucrose
• (D) Fructose

7. Depot fats of mammalian cells comprise mostly of

• (A) Cholesterol
• (B) Phospholipid
• (C) Cerebrosides
• (D) Triglycerol

8. When choline of lecithin is replaced by ethanolamine, the product is

• (A) Spingomyelin
• (B) Cephalin
• (C) Plasmalogens
• (D) Lysolecithin

9. Which of the following is a hydroxyl fatty acid?

•  (A) Oleic Acid
• (B) Ricinoleic acid
• (C) Caproic acid
• (D) Arachidonic acid

10. Acroleic test is given by

• (A) Cholesterol
• (B) Glycerol
• (C) Glycosides
• (D) Sphingol

11. Ketone bodies are synthesized from fatty acid oxidation products by which of the following organs?

• (A) Liver
• (B) Skeletal muscles
• (C) Kidney
• (D) Brain

12. Chain elongation of fatty acids occurring in mammalian liver takes place in which of the following subcellular fractions of the cell?

• (A) Nucleus
• (B) Ribosomes
• (C) Lysosomes
• (D) Microsomes

13. Which of the following cofactors or their derivatives must be present for the conversion of acetyl CoA to malonyl CoA extramitochondrial fatty acid synthesis?

• (A) Biotin
• (B) FAD
• (C) FMN
• (D) ACP

14. Which of the following statement regarding β-oxidation is true?

• (A) Requires β-ketoacyl CoA as a substrate
• (B) Forms CoA thioesters
• (C) Requires GTP for its activity
• (D) Yields acetyl CoA as a product

15. All statements regarding 3-OH-3 methyl glutaryl CoA are true except

• (A) It is formed in the cytoplasm
• (B) Required in ketogenesis
• (C) Involved in synthesis of Fatty acid
• (D) An intermediate in cholesterol biosynthesis

16. Which of the following lipoproteins would contribute to a measurement of plasma cholesterol in a normal individual following a 12 hr fast?

•  (A) Chylomicrons
• (B) VLDL
• (C) Both VLDL and LDL
• (D) LDL

17. All the following statements regarding ketone bodies are true except

• (A) They may result from starvation
• (B) They are formed in kidneys
• (C) They include acetoacetic acid and acetone
• (D) They may be excreted in urine

18. In synthesis of Triglyceride from α-Glycero phosphate and acetyl CoA, the first intermediate formed is

• (A) β-diacyl glycerol
• (B) Acyl carnitine
• (C) Monoacyl glycerol
• (D) Phosphatidic acid

19. During each cycle of β-oxidation of fatty acid, all the following compounds are generated except

• (A) NADH
• (B) H2O
• (C) FAD
• (D) Acyl CoA

20. The energy yield from complete oxidation of products generated by second reaction cycle of β-oxidation of palmitoyl CoA will be

• (A) 5 ATP
• (B) 12 ATP
• (C) 17 ATP
• (D) 34 ATP

21. β-Oxidation of odd-carbon fatty acid chain produces

• (A) Succinyl CoA
• (B) Propionyl CoA
•  (C) Acetyl CoA
• (D) Malonyl CoA

22. Brown adipose tissue is characterized by which of the following?

• (A) Present in large quantities in adult humans
• (B) Mitochondrial content higher than white adipose tissue
• (C) Oxidation and phosphorylation are tightly coupled
• (D) Absent in hibernating animals

23. Ketosis in partly ascribed to

• (A) Over production and Glucose
• (B) Under production of Glucose
• (C) Increased carbohydrate utilization
• (D) Increased fat utilization

24. The free fatty acids in blood are

• (A) Stored in fat depots
• (B) Mainly bound to β-lipoproteins
• (C) Mainly bound to serum albumin
• (D) Metabolically most inactive

25. Carnitine is synthesized from

• (A) Lysine
• (B) Serine
• (C) Choline
• (D) Arginine

26. A metabolite which is common to pathways of cholesterol biosynthesis from acetyl-CoA and cholecalciferol formation from cholesterol is

• (A) Zymosterol
• (B) Lumisterol
• (C) Ergosterol
• (D) 7 Dehydrocholesterol

27. Acetyl CoA required for extra mitochondrial fatty acid synthesis is produced by

• (A) Pyruvate dehydrogenase complex
• (B) Citrate lyase
• (C) Thiolase
• (D) Carnitine-acyl transferase

28. Biosynthesis of Triglyceride and Lecithine both require an intermediate:

•  (A) Monoacyl glycerol phosphate
• (B) Phosphatidic acid
• (C) Phosphatidyl ethanol amine
• (D) Phosphatidyl cytidylate

29. The rage limiting step cholesterol biosynthesis is

•  (A) Squalene synthetase
• (B) Mevalonate kinase
• (C) HMG CoA synthetase
•  (D) HMG CoA reductase

30. All the following are constituents of ganglioside molecule except

• (A) Glycerol
• (B) Sialic acid
• (C) Hexose sugar
• (D) Sphingosine

31. An alcoholic amine residue is present in which of the following lipids?

• (A) Phosphatidic acid
• (B) Cholesterol
• (C) Sphingomyelin
• (D) Ganglioside

32. Sphingosine is the backbone of all the following except

• (A) Cerebroside
• (B) Ceramide
• (C) Sphingomyelin
• (D) Lecithine

33. Chylomicron, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) and very low density lipoproteins (VLDL) all are serum lipoproteins. What is the correct ordering of these particles from the lowest to the greatest density?

• (A) LDL, IDL, VLDL, Chylomicron
• (B) Chylomicron, VLDL, IDL, LDL
• (C) VLDL, IDL, LDL, Chylomicron
• (D) Chylomicron, IDL, VLDL, LDL

34. A compound normally used to conjugate bile acids is

• (A) Serine
• (B) Glycine
• (C) Glucoronic acid
• (D) Fatty acid

35. Which of the following lipoproteins would contribute to a measurement of plasma cholesterol in a normal person following a 12 hr fast?

• (A) High density lipoprotiens
• (B) Low density lipoproteins
• (C) Chylomicron
• (D) Chylomicron remnants

36. Which of the following products of triacylglycerol breakdown and subsequent β-Oxidation may undergo gluconeogenesis?

• (A) Acetyl CoA
• (B) Porpionyl CoA
• (C) All ketone bodies
• (D) Some amino acids

37. Which of the following regulates lipolysis in adipocytes?

• (A) Activation of fatty acid synthesis mediated by CAMP
• (B) Glycerol phosphorylation to prevent futile esterification of fatty acids
• (C) Activation of triglyceride lipase as a result of hormone stimulated increases in CAMP levels
• (D) Activation of CAMP production by Insulin

38. Which one of the following compounds is a key intermediate in the synthesis of both triacyl glycerols and phospholipids?

•  (A) CDP Choline
• (B) Phosphatidase
• (C) Triacyl glyceride
• (D) Phosphatidyl serine

 39. During each cycle of on going fatty acid oxidation, all the following compounds are generated except

• (A) H2O
• (B) Acetyl CoA
• (C) Fatty acyl CoA
• (D) NADH

ANSWER:
1. A 2. B 3. C 4. B 5. B 6. D 7. D 8. B 9. B 10. B

11. A 12. D 13. A 14. A 15. B 16. D 17. B 18. D 19. B 20. D 21. D 22. B 23. D 24. C 25. A 26. D 27. B 28. B 29. D 30. A 31. C 32. D 33. B 34. B 35. A 36. B 37. C 38.  39. A